I've noticed a grand total of one change with the fall creator's update, task manager now shows GPU usage in addition to CPU, RAM, storage and network. Really glad they added that since EVGA's and MSI's monitoring stuff is garbage that rarely works.
I didn't have any problems, although I haven't tried my Thrustmaster T-Flight X since I updated. I also made sure I disconnected my Rift before I updated so that might have something to do with it.
The closest thing I encountered to an inconvenience is that my HOTAS configuration in Eve Valkyrie was reset; but the game itself just went through a major update which could be the culprit. This isn't the first time that a EV update reset my HOTAS config.
Overall I'm actually impressed with how smooth this Windows Update was rolled out.
Right now that's where I'm at. However, the numbers suggest that it seems OK to proceed with the update. The question remaining is to unplug it or leave it plugged in during the Windows "upgrade". I've seen success cases for both scenarios so it may not really matter.